Since 2010, we’ve set out to formulate the most comprehensive and effective Foundational Nutrition supplement.
Our driving belief? High-quality ingredients combined with healthy gut function could improve the body’s ability to absorb and actually use essential nutrients.
Our in-house team of doctors, scientists, and researchers worked with third-party experts to conduct a set of scientific studies and further validate the benefits of AG1. We followed a universally acknowledged hierarchy of scientific rigor, looking beyond ingredient data to test our complete formula and validate the synergy of how ingredients work together.
increase in healthy bacteria in the gut.¹
1 In a double-blind, randomized, placebo-controlled clinical trial assessing 30 healthy adults ages 21-49 over the course of 1 month.
increase in short-chain fatty acid production.¹
1 In an in vitro study conducted on 3 stool donors using a simulated model of the digestive tract in a controlled, laboratory design, AG1 was shown to improve indicators of gut health.
increase in serotonin production in the gut.¹
1 In an in vitro study conducted on 3 stool donors using a simulated model of the digestive tract in a controlled, laboratory design, AG1 was shown to improve indicators of gut health.
more minerals available for absorption vs. a multivitamin tablet.¹
1 In an in vitro study that compared AG1 powder to a multivitamin tablet using a simulated model of the digestive tract (SHIME).
At 1 month¹
At 3 months†
1 In a single-arm observational study conducted on 35 healthy adults ages 25-48 assessing the self-perceived efficacy of AG1 over 3 months.
“We intentionally designed AG1 to deliver a diverse spectrum of essential daily nutrients with pre and probiotics to support the gut, in a powder form that’s easier for your body to digest than a tablet.”*
Dr. Ralph Esposito ND, LAc — Functional Medicine, Chief Science & Nutrition Officer
Our Team & Findings
To contribute to the emerging body of research on foundational nutrition and to keep AG1 at the forefront of it, we rely on an in-house team of doctors, scientists, and researchers dedicated to bringing you the highest quality supplement.
Peer-reviewed research
In addition to sharing our results, we collaborate with other experts and researchers in the scientific community to publish research in peer-reviewed scientific journals, helping to lead the discourse on the complex and crucial role nutrition plays in overall health.
The effects of AG1® supplementation on the gut microbiome of healthy adults: a randomized, double-blind, placebo-controlled clinical trial
This study aimed to examine the effect of a commercially available multi-ingredient powder (AG1®) on the gut microbiome and assess the impact of AG1® on GI tolerability and other clinical safety markers in healthy men and women.
The Novel Synbiotic, AG1®, Increases Short-Chained Fatty Acid Production in the Simulator of Human Intestinal Microbial Ecosystem (SHIME) Model®
Recently, there is growing usage of prebiotics and probiotics as dietary supplements due to their purported health benefits. AG1® (AG1) is a novel foundational nutrition supplement which contains vitamins, minerals, phytonutrients, wholefood concentrates, adaptogens, and functional mushrooms.
AG1®, a Novel Synbiotic, Demonstrates Superior Mineral Bioaccessibility and Bioavailability Compared to a Tablet Multivitamin and Mineral Supplement Using an In Vitro Model of the Upper Gastrointestinal Tract
The study compared the bioaccessibility and bioavailability of minerals (magnesium, zinc, calcium, and potassium) in a traditional multivitamin tablet and a powder Foundational Nutrition supplement (AG1®), revealing that AG1 exhibited overall greater bioaccessibility and bioavailability during simulated upper gastrointestinal tract digestion.
AG1® Induces a Favorable Impact on Gut Microbial Structure and Functionality in the Simulator of Human Intestinal Microbial Ecosystem® Model
Considering previous experimental data on AG1 and the growing evidence that various phytochemicals can act as prebiotics, the primary objective of the current experiment was to detail the specific effects of AG1 on gut microbial community composition by observing changes in community structure and function.
AG1®, a Novel Synbiotic, Maintains Gut Barrier Function following Inflammatory Challenge in a Caco-2/THP1-Blue™ Co-Culture Model
Nutritional interventions to reduce gastrointestinal (GI) permeability are of significant interest to physically active adults and those experiencing chronic health conditions. This in vitro study was designed to assess the impact of AG1, a novel synbiotic, on GI permeability following an inflammatory challenge.
Changes in the fecal polar metabolome due to AG1 supplementation in the SHIME® model: A proof of principle study
Metabolomics is a critical approach to fully understand the metabolic repercussions of a nutritional supplement on the gut microbiota. Here, a proof of principle study was conducted via a metabolomic survey of polar metabolites to explore the effect of AG1 on the metabolic output of the human gut microbiota, in vitro, using the Simulator of the Human Intestinal Microbial Ecosystem® (SHIME).
Foundational Nutrition: Implications for Human Health
Human nutrition, and what can be considered “ideal” nutrition, is a complex, multi-faceted topic which many researchers and practitioners deliberate. While some attest that basic human nutrition is relatively understood, it is undeniable that a global nutritional problem persists.
Nutrient synergy: definition, evidence, and future directions
Nutrient synergy refers to the concept that the combined effects of two or more nutrients working together have a greater physiological impact on the body than when each nutrient is consumed individually.
The SHIME model, which stands for Simulator of the Human Intestinal Microbial Ecosystem, is an in vitro model used in research to study the human gastrointestinal tract. It consists of a series of interconnected sections, called bioreactors, that mimic the physiological and biological conditions found in the human gut, including the stomach, small intestine, and colon.
